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KMID : 0608520070130030157
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Korean Journal of Oriental Medicine
2007 Volume.13 No. 3 p.157 ~ p.163
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Quantitative analysis of anthraquinones in Polygonum multiflorum Thunberg
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Lee Hye-won
Park So-young
Choo Byung-kil
Lee A-eong
Kim Ho-kyoung
Chae Sung-wook
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Abstract
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Objective : Polygonum multiflorum Thunberg (Polygonaceae) has been traditionally used as a tonic and the purgative in China and Korea. The genus Polygonum is a source of a wide range of phenolic compound, flavanoids, anthraquinones, stilbenes and tannins. In this study, three anthraquinones were isolated and quantitative determination of anthraquinones from P multiflorum has been developed for quality standardization.
Methods : Three anthraquinone derivatives were isolated from a methanol extract of the radix of P. multiflorum by the chromatographic separation. Their structures were identified as emodin, physcion and ω-hydroxyemodin on the basis of spectral data (MS, 1H-NMR, 13C-NMR) and chemical analysis. HPLC analysis was performed to determine the contents of emodin, physcion, chrysophanol, rhein and ω-hydroxyemodin in P multiflorum from different specimens were collected from twenty Korean markets.
Results : According to the results, the contents of emodin, physcion, chrysophanol, rhein and ω-hydroxyemodin were 0.145%, 0.434%, 0.016%, 0.026%, 0.030% by HPLC, respectively.
Conclusions : In these results, we have determined the contents of emodin, physcion, chrysophanol, rhein and ω-hydroxyemodin in P. multiflorum, respectively. We hope that this study will contribute to the standardization and quality control of herbal medicine.
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KEYWORD
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Polygonum multiflorum, emodin, physcion, ω-hydroxyemodin
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